Prodrugs of benzofuranylmethyl carbamate nk, antagonists

Details Prodrugs of benzofuranylmethyl carbamate nk, antagonists Prodrugs of benzofuranylmethyl carbamate nk, antagonists

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/34 (2006.01) A61K 31/405 (2006.01) A61K 31/675 (2006.01) C07F 9/141 (2006.01) C07F 9/145 (2006.01) C07F 9/22 (2006.01) C07F 9/572 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2323047

The instant invention provides aqueous soluble prodrugs of formula (I) or a pharmaceutically acceptable salt thereof wherein R is -CH2OZ, -C(-O)OCH2OZ or Z, wherein Z is formula (a), P(-O)(OH)2 or -C(-O)Q: n is an integer of from 0 to 3; m is an integer of from 0 to 1, of certain tachykinin antagonists (NK1 antagonists) useful in the treatment of emesis.

L'invention concerne des promédicaments de certains antagonistes de tachykinine (antagonistes NK1), solubles dans un milieu aqueux, et utiles dans le traitement des vomissements, représentés par la formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci. Dans cette formule, R représente CH2OZ, -C(=O)OCH2OZ ou Z représente (a), -P(=O)(OH)2 ou -C(=O)Q:; n est un nombre entier compris entre 0 et 3; m est un nombre entier compris entre 0 et 1.

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