Prodrugs of carbamate inhibitors of impdh

Details Prodrugs of carbamate inhibitors of impdh Prodrugs of carbamate inhibitors of impdh

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/422 (2006.01) A61K 38/05 (2006.01) A61K 47/48 (2006.01) A61P 37/06 (2006.01) C07C 269/00 (2006.01) C07C 271/62 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2377278

The present invention relates to carbamate prodrugs of formula (I) that convert to active inhibitors of the IMPDH enzyme of formula (I') in vivo. The compounds and pharmaceutical compositions of this invention are particularly well suited for activation and subsequent inhibition of the IMPDH enzyme activity. Consequently, these prodrugs may be advantageously used as therapeutic agents for IMPDH mediated processes.

La présente invention se rapporte à des promédicaments de carbamates représentés par la formule (I), qui se transforment in vivo en inhibiteurs actifs de l'enzyme IMPDH représenté par la formule (I'). Les composés et compositions pharmaceutiques de cette invention s'avèrent particulièrement adaptés à l'activation et à l'inhibition subséquente de l'activité de l'enzyme IMPDH. Ces promédicaments peuvent par conséquent être avantageusement utilisés en tant qu'agents thérapeutiques destinés aux processus à médiation assurée par l'IMPDH.

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