C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 315/00 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) C07C 323/00 (2006.01)
Patent
CA 2542970
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. These prodrugs are far more soluble in aqueous media than the active agents into which they convert, in vivo. As such compounds of Formula (I) and (II) are advantageous for, among other things intravenous administration. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) and Formula (II).
L'invention concerne de nouveaux composés de formules (I) et (II) qui sont des promédicaments se convertissant <i>in vivo</i> en diaryl-2-(5H)-furanones utiles dans le traitement de maladies induites par cyclooxygénase-2. Ces promédicaments sont de loin plus solubles dans un milieu aqueux que les agents actifs dans lesquels ils se convertissent, <i>in vivo</i>. Ces composés de formules (I) et (II) sont, entre autres, avantageux dans l'administration intraveineuse. L'invention concerne également certaines compositions pharmaceutiques et des procédés de traitement de maladies induites par cyclooxygénase-2 comprenant l'utilisation des composés de formules (I) et (II).
Arruda Jeannie M.
Munoz Benito
Stearns Brian A.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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