C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/083 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2335992
The invention relates to prodrug compounds of inhibitors of dipeptidyl peptidase IV (DP IV). Said prodrug compounds comprise general formulas (A-B- C), whereby A represents an amino acid, B represents the chemical bond between A and C or an amino acid, and C represents a stabile inhibitor of DP IV. Such prodrug compounds are used for treating altered glucose tolerance, glucosuria, hyperlipidemia, metabolic acidoses, diabetes mellitus, diabetic neuropathy, nephropathy, and secondary diseases in mammals caused by diabetes mellitus.
L'invention concerne des composés prodicamenteux d'inhibiteurs de la dipeptidylpeptidase IV (DP IV), qui présentent la formule générale A-B-C dans laquelle A est un aminoacide, B est la liaison chimique entre A et C ou bien un aminoacide, et C un inhibiteur stable de la DP IV. Ces composés promédicamenteux s'utilisent pour traiter la tolérance glucidique altérée, la glucosurie, l'hyperlipidémie, les acidoses métaboliques, le diabète sucré, la neuropathie et la néphropathie diabétiques, ainsi que les maladies provoquées par le diabète sucré chez les mammifères.
Demuth Hans-Ulrich
Hoffmann Torsten
Manhart Susanne
Schlenzig Dagmar
Macrae & Co.
Probiodrug Gesellschaft Fur Arzneimittelforschung Mbh
Prosidion Limited
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