C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/415 (2006.01) A61P 31/04 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2492718
Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.
L'invention concerne des promédicaments des inhibiteurs de la pompe à protons représentés par les formules 1 à 4 (I-IV), dans lesquelles les symboles sont tels que définis dans la description et le groupe R comprend au moins un groupe acide ou son sel pharmaceutiquement acceptable. Ces promédicaments présentent une solubilité aqueuse et une biodisponibilité améliorées.
Garst Michael E.
Sachs George
Shin Jai Moo
Garst Michael E.
Gowling Lafleur Henderson Llp
Sachs George
Shin Jai Moo
The Regents Of The University Of California
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