Prodrugs of selective androgen receptor modulators and...

Details Prodrugs of selective androgen receptor modulators and... Prodrugs of selective androgen receptor modulators and...

C - Chemistry, Metallurgy

07

C

C07C 233/05 (2006.01) A01N 55/04 (2006.01)

Patent

CA 2522874

The present invention provides prodrugs of selective androgen receptor modulators (SARMs), and their use in treating or reducing the incidence of osteoporosis, a variety of hormone-related conditions, conditions associated with Androgen Decline in Aging Male (ADAM); conditions associated with Androgen Decline in Female (ADIF), and muscular wasting conditions, obesity, dry eye conditions, and prostate cancer. The prodrugs are also useful in oral and androgen replacement therapy and male contraception.

La présente invention concerne des promédicaments de modulateurs sélectifs des récepteurs aux androgènes (SARMs) et leur application dans le traitement ou la réduction de l'incidence de l'ostéoporose, de divers troubles hormonaux, de troubles associés au déclin androgénique chez l'homme âgé (ADAM) ; de troubles associés au déclin androgénique chez la femme (ADIF), et de troubles de fonte musculaire, de l'obésité, des troubles de sécheresse oculaire, et du cancer de la prostate. Ces promédicaments sont également utiles en thérapie de substitution androgénique par voie orale et en contraception masculine.

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