Prodrugs of thalidomide and methods for using same as...

A - Human Necessities – 61 – K

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A61K 31/445 (2006.01) A61K 38/05 (2006.01) A61K 47/48 (2006.01) C07K 5/062 (2006.01) C07K 5/068 (2006.01)

Patent

CA 2256669

The present invention relates to a new, safe and effective form of thalidomide ([N-phthalimido]-glutarimide) and methods of using the same. More specifically, the invention relates to prodrugs of thalidomide and prodrugs of certain analogs of thalidomide, which comprise a thalidomide or analog component having bound thereto the dipeptide sequence X-pro, wherein "X" is one of a wide variety of amino acids and "pro" represents the imino acid proline.

La présente invention porte sur une nouvelle forme de thalidomide ([N-phtalimido]-glutarimide) sûre et efficace et sur des procédés d'utilisation dudit produit. L'invention concerne plus particulièrement des prodrogues du thalidomide et des prodrogues de certains analogues du thalidomide comprenant un thalidomide ou un composant analogue ayant lié audit thalidomide la séquence X-pro du dipeptide dans laquelle "X" est un acide de la grande variété amino et "pro" représente la proline iminoacide.

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