Prodrugs of thrombin inhibitors

Details Prodrugs of thrombin inhibitors Prodrugs of thrombin inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/065 (2006.01) A61K 38/05 (2006.01) A61K 47/48 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2238737

There is provided compounds of formula (I): R1O(O)C-CH2-(R)Cgl-Aze-Pab-R2, wherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

La présente invention concerne des composés de formule (I): R?1¿O(O)C-CH¿2?-(R)Cgl-Aze-Pab-R?2¿, dans laquelle R?1¿ et R?2¿ ont la signification indiquée dans la description. Ces composés sont utiles comme promédicaments d'inhibiteurs de protéases analogues à la trypsine, comme la thrombine, en particulier dans le traitement de conditions dans lesquelles l'inhibition de la thrombine est nécessaire (par exemple la thrombose) ou comme anticoagulants.

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