Producer cells for replication selective viruses in the...

A - Human Necessities – 01 – N

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Details

A01N 63/00 (2006.01) A61K 35/54 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 1/20 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2323067

The invention includes producer cells for administering to a subject having tumor cells in order to kill tumor cells or prevent growth or spread of the tumor. The producer cell comprises an oncolytic virus which is capable of replicating in the producer cell. The producer cell is not capable of sustained survival in the body of the subject. The invention also includes methods of using these producer cells to treat a subject having tumor cells and making a medicament for use in such treatment.

L'invention se rapporte à des cellules productrices qu'il est possible d'administrer à un patient porteur de cellules cancéreuses dans le but de détruire lesdites cellules cancéreuses ou d'éviter la croissance ou la propagation de la tumeur. Une telle cellule productrice comporte un virus oncolytique qui est apte à la réplication dans ladite cellule productrice. La cellule productrice n'est pas capable de survivre de manière prolongée dans le corps du patient. L'invention se rapporte également à des méthodes d'utilisation de telles cellules productrices pour traiter un patient porteur de cellules cancéreuses et à des méthodes de fabrication d'un médicament pouvant être utilisé dans ce type de traitement.

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