Producing immunogenic constructs using soluble carbohydrates...

Details Producing immunogenic constructs using soluble carbohydrates... Producing immunogenic constructs using soluble carbohydrates...

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/39 (2006.01) C08B 37/00 (2006.01) C07K 17/10 (2006.01)

Patent

CA 2215933

The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, and covalently joining the activated first moiety to a second moiety. Preferably, the first moiety is a polysaccharide and the second moiety is a protein. Immunogenic constructs are prepared by this process using either direct or indirect conjugation of the first and second moieties.

L'invention concerne un procédé de préparation d'un produit de recombinaison immunogène consistant à activer au moins une première fraction contenant des hydrates de carbone au moyen de CDAP et à établir une liaison covalente entre la première fraction activée et une deuxième fraction. De préférence, la première fraction est un polysaccharide et la deuxième fraction est une protéine. Ce procédé permet de préparer des produits de recombinaison immunogènes au moyen d'une conjugaison directe ou indirecte de la première et de la deuxième fractions.

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