Producing monoclonal antibodies against human t-cell...

Details Producing monoclonal antibodies against human t-cell... Producing monoclonal antibodies against human t-cell...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) C07K 14/72 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2088905

2088905 9202629 PCTABS00010 Recombinant DNA vectors which express chimeric T cell receptors are disclosed. These chimeric T cell receptors contain one human element, and the rest of the elements are all of the same, non-human animal species, such as a mouse. Of particular interest are chimeras where the human element is V.alpha. or V.beta.. The vectors are used to transfect cells which derive from te same non-human animal species as the non-human animal species of the chimera, and the resulting transfectants are used to produce monoclonal antibodies against the human element of the chimera.

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