Product and process for inhibition of biofilm development

Details Product and process for inhibition of biofilm development Product and process for inhibition of biofilm development

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/522 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01)

Patent

CA 2578478

Disclosed are compositions and methods for the inhibition of biofilm formation or reduction of existing or developing biofilms in a patient. These methods also inhibit the aggregation of bacteria that form biofilms in the airways. The methods include administering to a subject that has or is at risk of developing biofilms a compound or formulation that inhibits the formation or polymerization of actin microfilaments or depolymerizes actin microfilaments at or proximal to the site of biofilm formation. Such a compound can be administered in combination with a compound or formulation that inhibits the accumulation or activity of cells that are likely to undergo necrosis at or proximal to the site of biofilm formation (i.e., neutrophils). The methods and compositions can further include the use of anti-DNA and/or anti-mucin compounds, as well as other therapeutic compounds and compositions.

L'invention concerne des compositions et des méthodes permettant d'empêcher la formation d'un film biologique ou de réduire les films biologiques existants ou en formation chez un patient. Ce méthodes empêchent en outre l'agrégation des bactéries formant un film biologique dans les voies respiratoires. Les méthodes décrites consistent à administrer à un sujet présentant des films biologiques ou risquant l'apparition de ces derniers un composé ou une préparation qui inhibe la formation ou la polymérisation des microfilaments d'actine, ou dépolymérise les microfilaments d'actine, dans le site de formation de film biologique ou à proximité de celui-ci. Ce composé peut être administré en combinaison avec un composé ou une préparation qui inhibe l'accumulation ou l'activité des cellules risquant de subir une nécrose dans le site de formation du film biologique ou à proximité de celui-ci (neutrophiles). Ces méthodes et ces compositions peuvent en outre comprendre l'utilisation de composés anti-ADN et/ou anti-mucine, ainsi que d'autres composés et compositions thérapeutiques.

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