A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 14/05 (2006.01) C07K 14/15 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 14/735 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2184631
Products and processes are disclosed for regulating signal transduction pathways in cells. One aspect of the invention relates to a peptide having a YXXLXXXXXXXYXX amino acid motif that is useful in regulating the activity of tyrosine kinases, lipid kinases and adaptor molecules. A separate aspect of the present invention relates to a product and process for inhibiting signal transduction pathways in cells involving a peptide capable of binding to an SH3 domain of a tyrosine kinase, thereby blocking the binding and activation of an effector by the tyrosine kinase. Both the above compound and peptide composition can be useful in the treatment of medical disorders such as allergic responses, autoimmune diseases, inflammatory responses, cancer, immunodeficiency diseases, immunoproliferative diseases and diseases caused by viruses, such as EBV and BLV.
L'invention concerne des produits et des procédés de régulation de voies de transduction de signaux dans des cellules. L'invention se rapporte d'une part, à un peptide présentant un motif aminoacide YXXLXXXXXXXYXX? et utile dans la régulation de l'activité des tyrosine-kinases, des lipide-kinases et des molécules d'adaptation. Elle porte, d'autre part, sur un produit et un procédé d'inhibition de voies de transduction de signaux dans des cellules impliquant un peptide capable de se lier au domaine SH3 d'une tyrosine-kinase, pour bloquer ainsi la liaison et l'activation d'un effecteur par la tyrosine-kinase. Le composé et la composition peptidique peuvent être utilisés dans le traitement de troubles médicaux tels que les réactions allergiques, les maladies auto-immunes, les réactions inflammatoires, le cancer, les déficiences immunitaires, les maladies immunoprolifératives et celles dues à des virus tels que le virus Epstein-Barr et le virus de la leucémie bovine.
Cambier John C.
Clark Marcus R.
Pleiman Christopher M.
Borden Ladner Gervais Llp
National Jewish Center For Immunology And Respiratory Medicine
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