Production and characterization of hybridoma antibodies...

C - Chemistry – Metallurgy – 12 – P

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167/139, 167/37,

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C12N 5/18 (2006.01)

Patent

CA 1306961

31 ABSTRACT OF THE INVENTION The present inventions relate to production, detection of, and characterization of monoclonal antibodies/hybridoma antibodies (and the corresponding hybridoma cells including derived hybrid cells) which are able to recognize proteins (or part(s) thereof) belonging antigenically to the Human Leukocyte Interferon System (HuIFN-.alpha.) - be the said proteins produced natively (for example by white blood cells) or produced by recombinant techniques (genetic engineering) or produced by peptide derivation of the said proteins or part(s) thereof) - exhibiting the same common antigenic determinant(s) as found to be common in the native HuIFN-.alpha. system. Such antibodies (or the relevant part(s) thereof) can be used as "universal" antibodies for purification and characterization of all the above mentioned proteins belonging to the HuIFN-.alpha. system.

473060

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