Production and use of human and plant methyltransferases

Details Production and use of human and plant methyltransferases Production and use of human and plant methyltransferases

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01N 3/00 (2006.01) A61K 38/45 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2203265

An isolated recombinant human L-isoaspartyl/D-aspartyl protein methyltransferase is obtained by overexpression of cDNA coding for isozyme II in an E. coli strain, and a cDNA clone of the wheat enzyme and a purified enzyme from wheat are obtained. These enzymes are useful in treatment of medical conditions and diagnosis of disease associated with an increase in L- isoaspartyl/D-aspartyl residues of polypeptides in a tissue.

On obtient une L-isoaspartyle/D-aspartyle protéine méthyltransférase recombinante isolée de l'homme par surexpression d'ADNc codant pour l'isozyme II dans une souche de E.coli et on obtient un clone d'ADNc de l'enzyme du blé, ainsi qu'une enzyme purifiée à partir du blé. Ces enzymes sont utiles dans le traitement d'états pathologiques et dans le diagnostic de maladies associées à une augmentation de restes de L-isoaspartyle/D-aspartyle de polypeptides dans un tissu.

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