Production and use of porphyrins

Details Production and use of porphyrins Production and use of porphyrins

C - Chemistry, Metallurgy

12

P

167/215, 167/231

C12P 17/18 (2006.01) A61K 31/19 (2006.01) A61K 31/24 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) A61K 49/00 (2006.01) A61N 5/06 (2006.01)

Patent

CA 2004979

Abstract Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating said cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in said cells thereby causing a buildup of protoporphyrin IX in said cells. Also disclosed is a method for the production of protoporphrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphrinogen oxidase inhibitor.

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