Production and use of recombinant protein multimers with...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/62 (2006.01) A61K 38/18 (2006.01) C07K 14/505 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2296071

The invention relates to recombinant fusion proteins, either with or without peptide linkers, with or without variations in noncoding regions of the protein. The fusion proteins have altered structural and functional properties and biological activity. The fusion proteins can be used, for example, as in vivo therapeutics.

La présente invention concerne des protéines hybrides recombinées, pourvues ou dépourvues de segment de liaison de peptide, comprenant ou non des variations dans les régions non codantes de la protéine. Ces protéines hybrides possèdent des propriétés structurelles et fonctionnelles et une activité biologique modifiées. Les protéines hybrides peuvent être utilisées, par exemple, comme agents thérapeutiques in vivo.

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