Production method

Details Production method Production method

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01)

Patent

CA 2732204

The invention relates to the development of microorganisms that produce 1,2- propanediol (1,2-PD) from glycerol, whereas glycerol is simultaneously the substrate carbon source for 1,2-PD- and biomass production. The invention demonstrates that any type of glycerol serves as carbon substrate for 1,2-PD biosynthesis. The microorganism is a recombinant organism, preferentially an E. coli K12 strain or a derivative thereof, particularly a strain, which is inactivated in competing pathways that lower 1,2-PD production.

Linvention concerne le développement de microorganismes qui produisent du 1,2-propanediol (1,2-PD) à partir de glycérol, le glycérol étant simultanément la source de charbon substrat pour la production d1,2-PD et de biomasse. Linvention démontre que nimporte quel type de glycérol sert de charbon substrat pour la biosynthèse d1,2-PD. Le microorganisme est un organisme recombinant, de préférence une souche dE. coli K12 ou un dérivé correspondant, notamment une souche, dont les voies réactionnelles en compétition, qui réduisent la production d1,2-PD, sont désactivées.

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