Production method of 1-substituted-1,2,3-triazole derivatives

Details Production method of 1-substituted-1,2,3-triazole derivatives Production method of 1-substituted-1,2,3-triazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 249/04 (2006.01) A61K 31/422 (2006.01) A61P 9/10 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 263/32 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2415961

A method for producing (I) or (II), characterized in that (III) and (IV) are reacted (1) in a secondary or tertiary alcohol in the presence of a base or (2) in the absence of a base. The method can be employed for producing a 1- substituted-1,2,3-triazole compound having inhibitory action for tyrosine kinase, in a high yield and with a simple and easy process, on a commercial scale.

Cette invention concerne un procédé de fabrication de (I) ou de (II), caractérisé en ce que (III) et (IV) réagissent (1) dans un alcool secondaire ou tertiaire en présence d'une base ou (2) en l'absence d'une base. Ce procédé convient pour la fabrication simple, facile et à grande échelle d'un composé 1, 2, 3 triasol substitué en position 1 une action inhibante pour la tyrosine kinase.

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