Production method of citalopram, intermediate therefor and...

Details Production method of citalopram, intermediate therefor and... Production method of citalopram, intermediate therefor and...

C - Chemistry, Metallurgy

07

D

C07D 307/81 (2006.01) C07C 29/40 (2006.01) C07C 33/46 (2006.01) C07C 45/68 (2006.01) C07C 49/813 (2006.01) C07C 51/265 (2006.01) C07C 51/373 (2006.01) C07C 65/34 (2006.01) C07D 307/80 (2006.01) C07D 307/87 (2006.01)

Patent

CA 2318701

Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula [VI] with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N',N'-tetramethylethylenediamine and 1,3- dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula [III], which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula [II] to reduction and cyclization. Image

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