Production method of liposome dispersion and production...

B - Operations – Transporting – 01 – J

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B01J 13/04 (2006.01) A61K 9/127 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2649025

An industrially useful process for producing a liposome dispersion. In the step of liposome formation through the dispersion of a membrane substance in an aqueous medium, a liquid obtained by dissolving or dispersing the membrane substance and the aqueous medium are ejected respectively through (161a) and (161b) and, simultaneously therewith, these ejection flows are pulverized en bloc into fine droplets with a high-speed air flow ejected through a liquid ejection opening (162). The resultant droplets are caused to collide against a flow check object (190) to cause reaggregation and thereby produce the target dispersion. This production process facilitates solvent removal and does not necessitate a defoaming operation. Thus, a liposome dispersion can be efficiently prepared.

On décrit un procédé utile du point de vue industriel, qui permet de produire une dispersion de liposomes. A l'étape de la formation des liposomes par la dispersion d'une substance membranaire dans un milieu aqueux, un liquide obtenu par dissolution ou dispersion de la substance membranaire et le milieu aqueux sont éjectés respectivement à travers (161a) et (161b) et, simultanément avec celles-ci, les flux d'éjection sont pulvérisés en bloc en fines gouttelettes, au moyen d'un flux d'air à haute vitesse éjecté par une ouverture d'éjection du liquide (162). Les gouttelettes résultantes sont amenées à entrer en collision avec un objet de contrôle du flux (190), ce qui provoque la réagrégation et produit ainsi la dispersion cible. Ce procédé de production facilite l'élimination des solvants et ne nécessite pas une opération de démoussage. Ainsi, une dispersion de liposomes peut être préparée de manière efficace.

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