Production of 12-dihydro steroids

Details Production of 12-dihydro steroids Production of 12-dihydro steroids

C - Chemistry, Metallurgy

12

P

195/19

C12P 19/00 (2006.01)

Patent

CA 1072467

ABSTRACT OF THE DISCLOSURE A method of producing a 12-dihydro steroid, particularly a 3,7-disubstituted-12-dihydro steroid such as 3.alpha.,7.alpha.-dihydroxy- 5.beta.-cholanic acid, by subjecting a 12-hydroxy steroid to the action of a 12-dehydroxylase producing microorganism in a suitable medium The 12-hydroxy steroid may be subjected to the action of the microorganism itself or a 12-dehydroxylase enzyme produced by the microorganism. The microorganism is preferably one from the group of Clostridium and Bifidobacterium, especially Clostridium perfringens and Clostridium welchii. The 12-dihydro steroids have desirable pharmacological properties such as hypolipidemic activity.

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