Production of 2,3'-anhydro-2'-deoxyuridine derivatives

Details Production of 2,3'-anhydro-2'-deoxyuridine derivatives Production of 2,3'-anhydro-2'-deoxyuridine derivatives

C - Chemistry, Metallurgy

07

H

260/229.2

C07H 19/073 (2006.01) C07H 19/06 (2006.01)

Patent

CA 1316918

Abstract "Production of 2,3'-anhydro-2'-deoxyuridine derivatives" A process for the production of a 5-substituted derivative of a 2,3'-anhydro-2'-deoxyuridine preferably corresponding to the following general formula: Image wherein R1 represents H, alkyl, aryl, halogeno or CF3; characterised in that it comprises heating a 5-substituted derivative of a 2'-deoxyuridine preferably corresponding to the followlng general formula: Image wherein R1 is as defined above; in the presence of a sulphite transfer reagent and preferably a solvent is disclosed. This process improves the production of valuable intermediates and hence facilitates and reduces the cost of production of pharmacologically-interesting compounds.

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