C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/206.3
C07D 519/02 (2006.01) C07D 457/12 (2006.01)
Patent
CA 1294956
ABSTRACT OF THE DISCLOSURE: 2-Bromo-alpha-ergocryptine, the potent inhibitor of prolactin /luteotropic hormone/, is prepared in high yield and purity grade by the bromination of alpha-ergocryp- tine with elemental bromine in chlorinated aliphatic hydrocarbons and/or tetrahydrofuran in the presence of catalytic amounts of Lewis acids, preferably boron tri- fluoride, in the temperature range of from -40 to 0°C and optionally converted as known per se into its acid addition salt, preferably methanesulfonate.
576777
Benes Karel
Cvak Ladislav
Flieger Miroslav
Krajicek Alois
Opalka Miroslav
Robic
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
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