Production of 2-keto-d-gluconic acid and hydrogen peroxide

C - Chemistry – Metallurgy – 12 – P

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C12P 7/58 (2006.01) C07D 307/62 (2006.01) C07H 7/027 (2006.01) C12N 9/04 (2006.01) C12N 9/08 (2006.01) C12P 3/00 (2006.01) C12P 7/04 (2006.01) C12P 17/02 (2006.01) C12P 17/06 (2006.01) C12P 19/02 (2006.01)

Patent

CA 1163221

PRODUCTION OF 2-KETO-D GLUCONIC ACID AND HYDROGEN PEROXIDE ABSTRACT A process is described which is useful as a co-process in combination with a process which employs hydrogen peroxide. The process of the invention provides a source of hydrogen peroxide along with a useful co- product, that co-product being 2-keto-D-gluconic acid or products derived therefrom. One of the first and second carbons of D-glucose is oxidized enzymatically to produce hydrogen peroxide and an intermediate product. The other of the first and second carbons of the intermediate product is then oxidized enzymatically to produce hydrogen peroxide and 2-keto-D-gluconic acid. In one form of the invention, the intermediate product is D-glucosone; the final pro- duct is 2-keto-D-gluconic acid. In the other form of the invention, the intermediate product is D-glucono-.delta.-lactone; the final product is a mixture of 2-keto-D-gluconic acid and D-isoascorbic acid.

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