Production of a contractile smooth muscle

Details Production of a contractile smooth muscle Production of a contractile smooth muscle

C - Chemistry, Metallurgy

12

N

C12N 5/077 (2010.01) A61K 35/34 (2006.01)

Patent

CA 2209211

A contractile smooth muscle cell construct and a method for preparing the smooth muscle cell construct are described. The smooth muscle cell construct is comprised of (i) smooth muscle cells that have been cultured in vitro under conditions to allow the formation of a sheet of smooth muscle cells and (ii) an endogenous fibrous matrix formed by the smooth muscle cells, wherein the smooth muscle cell construct retains the ability to contract in response to vasoactive agonists. The smooth muscle cell construct may be prepared in planar or tubular form and can be used to study or evaluate the contractile responses of smooth muscle cells.

La présente invention décrit la construction cellulaire d'un muscle lisse contractile ainsi que son procédé de fabrication. La construction cellulaire du muscle lisse comprend: i) des cellules de muscle lisse cultivées in vitro dans des conditions propres à permettre la formation d'une couche de cellules de ce type et ii) une matrice de fibres endogènes formée par les cellules de muscle lisse, dans laquelle la construction cellulaire d'un muscle lisse a la capacité de se contracter en réaction à des agonistes vasoactifs. Cette construction cellulaire d'un muscle lisse, qui peut être réalisée sous une forme plane ou tubulaire, peut servir à étudier ou à évaluer les réactions contractiles des cellules d'un muscle lisse.

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