Production of a homogeneous cell line highly permissive to...

A - Human Necessities – 61 – K

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A61K 39/12 (2006.01) C12N 7/02 (2006.01)

Patent

CA 2687146

Continuous cell lines that are highly permissive to infection by porcine circovirus type 2 ("PCV2") are described. PCV2 is the causal agent of post-weaning multi-systemic wasting syndrome ("PMWS") in pigs. PMWS has emerged as a major disease that poses a significant threat to the economics of global swine industry. The highly permissive cell lines of this invention provide efficient and reliable sources of PCV2 for use in development of vaccines, therapies and diagnostic agents for PMWS.

La présente invention concerne des lignées continues de cellules hautement sensibles à une infection par le circovirus porcin de type 2 (PCV2). Le PCV2 est l'agent à l'origine du syndrome de dépérissement post-sevrage (SDPS) chez le cochon. Le SDPS est devenu une maladie majeure qui menace de façon significative l'économie de l'industrie porcine mondiale. Les lignées de cellules hautement sensibles de la présente invention fournissent une source efficace et fiable de PCV2, utilisables dans le cadre de la mise au point de vaccins, de traitements et d'agents de diagnostic pour le SDPS.

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