Production of a vitamin c precursor using genetically...

Details Production of a vitamin c precursor using genetically... Production of a vitamin c precursor using genetically...

C - Chemistry, Metallurgy

12

N

195/114, 195/1.2

C12N 15/74 (2006.01) C12N 1/21 (2006.01) C12N 9/04 (2006.01) C12N 15/53 (2006.01) C12P 7/60 (2006.01) C12P 17/04 (2006.01)

Patent

CA 1305438

ABSTRACT An enzyme for conversion of 2,5-diketo- D-gluconate (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) and a genetically modified organism that expresses all the fermentation enzymes needed to convert glucose to 2-KLG (a precursor to ascorbic acid) using the new enzyme are described. Prefer- ably, the organism is Erwinia citreus, or a mutated strain of Erwinia citreus, unable to use 2,5-DKG or 2-KLG as a sole carbon source, into which the gene for a 2,5-DKG reductase, produced by Corynebacterium sp, SHS 752001, has been inserted. The preferred transformed organism expresses the fermentation enzymes Erwinia citreus normally expresses for fermentation of glucose to 2,5-DKG and, in addition, an enzyme Corynebacterium sp. SHS 752001 expresses for fermentation of 2,5-DKG to 2-KLG. B.1238

515243

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