C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 231/10 (2006.01) C07C 233/25 (2006.01)
Patent
CA 2046763
ABSTRACT N-acetyl-para-aminophenol is prepared by contacting 4-hydroxyacetophenone oxime with a Beckmann rearrangement catalyst in an alkyl alkanoate reaction solvent. An integrated process is disclosed wherein 4-hydroxyacetophenone is reacted with a hydroxylamine salt and a base to obtain 4-hydroxyacetophenone oxime, the oxime product is extracted from the resulting reaction mixture with a substantially water- immiscible solvent, and the mixture of oxime and substantially water-immiscible solvent is contacted with a Beckmann rearrangement catalyst to produce N-acetyl-para-aminophenol. Novel Beckmann rearrangement catalysts are used to limit by-product formation in the ester solvent.
Aguilar Daniel A.
Fritch John R.
Fruchey O. Stanley
Hilton Charles B.
Horlenko Theodore
Aguilar Daniel A.
Fritch John R.
Fruchey O. Stanley
Hilton Charles B.
Hoechst Celanese Corporation
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