C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/39.1, 195/1.
C12N 15/56 (2006.01) C12N 1/19 (2006.01) C12N 9/36 (2006.01) C12N 15/81 (2006.01)
Patent
CA 1340063
The present invention provides a method of producing at high levels an animal lysozyme c by culturing Pichia pastoris cells, which have a gene capable of expressing the pre-form of the animal lysozyme c in such cells, under conditions such that the gene is transcribed. Mature animal lysozyme c is secreted at a high level from such cells into the culture medium, when the cells are cultured under conditions such that the animal pre-lysozyme c gene is transcribed in them. Also provided by the invention are DNAs capable of transforming Pichia pastoris to express animal pre-lysozyme c's, cultures of P. pastoris cells transformed with such DNAs, bovine pre-lysozyme c2, the signal peptide of bovine pre-lysozyme c2, and DNAs encoding those polypeptides.
581993
Digan Mary Ellen
Ellis Steven Bradley
Harpold Michael Miller
Lair Stephen Vernon
Siegel Robert Steven
Macrae & Co.
Merck Sharp & Dohme Corp.
The Salk Institute Biotechnology/industrial Associates Inc.
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