C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/32 (2006.01) A01N 37/18 (2006.01) A01N 63/04 (2006.01) C07K 14/32 (2006.01) C12N 1/19 (2006.01) C12N 15/81 (2006.01)
Patent
CA 2101610
ABSTRACT The present invention relates to a novel microbiological process for producing insecticidal toxins using recombinant DNA technology and more particularly to the production in methylotrophic yeast cells, especially those of the species Pichia pastoris, of larvicidal toxin polypeptides which are indigenous to entomocidal Bacillus spec and strains. This novel and efficient method produces large quantities of biologically active Bacillus entomotoxin compositions, by culturing cells of a species of methylotrophic yeast which harbor a heterologous gene for expressing a Bacillus entomotoxin polypeptide under conditions such that the heterologous gene ifs transcribed int he cells. The methyloptrophic yeast cells are an attractive food and are readily ingested by susceptible insect larvae, such that the entomotixin polypeptide may be efficiently delivered to the gut of the target insect where it takes effect.
Barr Kathryn A.
Davis Geneva R.
Hopkins Sharon A.
Koutz Patricia
Prevatt William D.
Osler Hoskin & Harcourt Llp
Research Corportation Technologies Inc.
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