Production of .beta.-form thiamine hydrochloride crystals

Details Production of .beta.-form thiamine hydrochloride crystals Production of .beta.-form thiamine hydrochloride crystals

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/51 (2006.01)

Patent

CA 2077886

Abstract A method of producing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.- form thiamine hydrochloride crystals in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture and a method of producing pharmaceutical preparations containing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.- form thiamine hydrochloride crystals, together with a binder, with water in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture. .beta.-Form thiamine hydrochloride crystals which are stable and resistant to caking and pharmaceutical preparations containing the same can be produced in a simple and easy manner.

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