Production of biofilaments in transgenic animals

Details Production of biofilaments in transgenic animals Production of biofilaments in transgenic animals

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/027 (2006.01) C07K 14/435 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2323570

Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and transgenic cells which secrete the biofilaments into culture media. Such a method is useful for producing large quantities of biofilament material. Also disclosed is a nucleic acid molecule for generating such transgenic animals.

L'invention concerne un procédé de production recombinante de biofilaments, tels que la soie d'araîgnée ou des fibroines d'insectes, à l'aide d'animaux transgéniques qui sécrètent les biofilaments dans leur lait et/ou leur urine, et des cellules transgéniques qui sécrètent les biofilaments dans des supports de cultures. Une telle méthode est utilisée pour produire de grandes quantités de biofilaments. L'invention concerne également une molécule d'acide nucléique destinée à générer de tels animaux transgéniques.

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