Production of biologically active, recombinant members of...

C - Chemistry – Metallurgy – 12 – N

Patent

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530/13, 530/3.08

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 1/113 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 14/50 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2038669

This invention describes processes for producing mature human members of the NGF/BDNF family of neurotrophic proteins that are fully biologically active. In addition, the gene encoding human BDNF and human BDNF are disclosed. A previously-unreported member of the NGF/BDNF family of neurotrophic proteins, NGF-3, has been identified and a portion of the gene encoding for the NGF-3 has been described.

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