Production of cartilage tissue using cells isolated from...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/08 (2006.01) A61K 35/32 (2006.01) A61K 35/44 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2269121

The invention relates to the isolation and use of pre-chondrocytes from the umbilical cord, specifically from Wharton's jelly, that give rise to chondrocytes which produce cartilage. The isolated pre-chondrocytes, or the chondrocytes to which they give rise, can be mitotically expanded in culture and used in the production of new cartilage tissue for therapeutic use. "Banks" of pre-chondrocytes or chondrocytes can be stored frozen, and thawed and used to produce new cartilage tissue as needed.

L'invention concerne l'isolement et l'utilisation de pré-chondrocytes provenant du cordon ombilical, spécifiquement de la gelée de Wharton, qui donnent naissance à des chondrocytes produisant du cartilage. Les pré-chondrocytes isolés, ou les chondrocytes auxquels ils donnent naissance, peuvent être développés par mitose en culture et être utilisés pour produire un nouveau tissu cartilagineux à des fins thérapeutiques. Des "banques" de pré-chondrocytes ou de chondrocytes peuvent être stockées congelées, puis décongelées et utilisées pour produire un nouveau tissu cartilagineux en fonction des besoins.

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