C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/08 (2006.01) A61K 35/32 (2006.01) A61K 35/44 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2269121
The invention relates to the isolation and use of pre-chondrocytes from the umbilical cord, specifically from Wharton's jelly, that give rise to chondrocytes which produce cartilage. The isolated pre-chondrocytes, or the chondrocytes to which they give rise, can be mitotically expanded in culture and used in the production of new cartilage tissue for therapeutic use. "Banks" of pre-chondrocytes or chondrocytes can be stored frozen, and thawed and used to produce new cartilage tissue as needed.
L'invention concerne l'isolement et l'utilisation de pré-chondrocytes provenant du cordon ombilical, spécifiquement de la gelée de Wharton, qui donnent naissance à des chondrocytes produisant du cartilage. Les pré-chondrocytes isolés, ou les chondrocytes auxquels ils donnent naissance, peuvent être développés par mitose en culture et être utilisés pour produire un nouveau tissu cartilagineux à des fins thérapeutiques. Des "banques" de pré-chondrocytes ou de chondrocytes peuvent être stockées congelées, puis décongelées et utilisées pour produire un nouveau tissu cartilagineux en fonction des besoins.
Naughton Brian A.
Purchio Anthony F.
San Roman Julia
Advanced Tissue Sciences Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
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