Production of cephalosporins

Details Production of cephalosporins Production of cephalosporins

C - Chemistry, Metallurgy

07

D

260/107, 260/101

C07D 501/20 (2006.01) C07D 501/59 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1130278

ABSTRACT In the preferred embodiment of the present inven- tion trimethylsilyl 7-trimethylsilyloxycarbonylaminodecepha- losporanate was prepared by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylamino- decephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephelexin by its acylation in anyhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em- 4-carboxylic acids or esters having a variety of substituents at the 3-position.

336416

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