Production of chimeric antibodies by homologous recombination

Details Production of chimeric antibodies by homologous recombination Production of chimeric antibodies by homologous recombination

C - Chemistry, Metallurgy

12

N

195/1.114, 195/1

C12N 15/62 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/64 (2006.01)

Patent

CA 1334177

A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.

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