Production of chimeric human papillomavirus

Details Production of chimeric human papillomavirus Production of chimeric human papillomavirus

A - Human Necessities

61

K

A61K 39/12 (2006.01) C07K 14/025 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/37 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2415763

This invention relates to infectious chimeric papillomaviruses, and especially those where the early genes are from human papillomavirus (HPV) 18, and the late genes are from another HPV. Also presented are methods of culturing the virus in raft cell cultures, and to assays utilizing these chimeric viruses.

L'invention concerne des papillomavirus chimériques infectieux, notamment ceux dont les gènes précoces proviennent du papillomavirus humain (HPV) 18 et dont les gènes tardifs proviennent d'un autre HPV. L'invention concerne également des procédés de mise en culture du virus dans des cultures cellulaires à matrice cutanée et des dosages utilisant ces virus chimériques.

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