Production of diphtheria toxin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 1/20 (2006.01) A61K 39/05 (2006.01) A61P 31/04 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2546769

A Corynebacterium diphtheriae culture medium for the production of diphtheria toxin and methods for producing the toxin are provided. The medium is substantiallty free of animal-derived products and comprises water, a carbohydrate source, a nitrogen source and a number of free amino acids in an initial concentration wherein the initial concentration of each free amino acid is not limiting for the production of the toxin.

L'invention a pour objet un milieu de culture de corynebacterium diphtheriae assurant la production d'une toxine de diphtérie et des procédés de production de ladite toxine. Le milieu est pratiquement exempt de produits dérivés d'animaux et comprend de l'eau, une source d'hydrate de carbone, une source d'azote, un certain nombre d'acides aminés libres selon une concentration initiale dans laquelle chaque acide aminé libre n'est pas déterminant pour la production de la toxine.

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