Production of dobutamine compounds

Details Production of dobutamine compounds Production of dobutamine compounds

C - Chemistry, Metallurgy

07

C

C07C 215/48 (2006.01) C07C 213/02 (2006.01) C07C 213/08 (2006.01) C07C 215/52 (2006.01) C07C 215/54 (2006.01)

Patent

CA 2120863

Abstract The invention relates to a process for the production of an acid addition salt of a dobutamine compound of the general formula Image (I) wherein R is a hydrogen atom or a methyl group, and n is 1 or 2, by reacting a mineral acid - addition salt of a dopamine compound of the general formula Image (II) with a ketone of the general formula Image (III) under the influence of a catalytic amount of a base, and in the presence of hydrogen and a hydrogenation catalyst, after which the pH of the reaction mixture is adjusted to approx. 6 at most and the product is isolated.

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