Production of e. coli lt-b enterotoxin subunit

Details Production of e. coli lt-b enterotoxin subunit Production of e. coli lt-b enterotoxin subunit

C - Chemistry, Metallurgy

07

K

167/129, 167/139

C07K 14/245 (2006.01) A61K 39/108 (2006.01) A61K 39/40 (2006.01) C07K 14/28 (2006.01) C07K 16/12 (2006.01) G01N 33/569 (2006.01)

Patent

CA 1340372

Methods and compositions are provided for the cloning and expression of genes coding for the non-toxic subunit of the heat-labile enterotoxin (LT-B) of E. coli. The LT-B thus produced may be formulated for use as an immunogen in vaccines. Specific antibodies produced by this invention may be used in diagnostic tests for the detection of Vibrio cholerae or LT positive enterotoxigenic E. coli. The antibodies of this invention may further be formulated into passive vaccines for the prophylactic or therapeutic protection of human beings or other mammalian species against diarrheal diseases caused by Vibrio cholerae or by the LT positive enterotoxigenic E. coli or other bacteria.

486088

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