Production of exogenous peptide in milk

Details Production of exogenous peptide in milk Production of exogenous peptide in milk

C - Chemistry, Metallurgy

12

N

119/75, 195/1.22

C12N 15/62 (2006.01) A01K 67/027 (2006.01) C07K 14/575 (2006.01) C07K 14/76 (2006.01) C07K 14/81 (2006.01) C07K 19/00 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12N 15/89 (2006.01) C12P 1/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1340723

A method of producing a substance comprising a peptide, involves incorporating a DNA sequence coding for the peptide into a gene of a mammal (such as a sheep) coding for a milk whey protein in such a way that the DNA sequence is expressed in the mammary gland of the adult female mammal. The substance may be an (optionally modified) protein such as a blood coagulation factor. The DNA sequence is preferably inserted into the first exon of a gene coding for a whey protein such as beta-lactoglobulin. The substance will generally be recovered from milk of the female mammal, but may (for example if it is an enzyme) be used in situ.

540942

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