Production of fc-fusion polypeptides in eukaryotic algae

Details Production of fc-fusion polypeptides in eukaryotic algae Production of fc-fusion polypeptides in eukaryotic algae

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) C07K 19/00 (2006.01) C12N 1/13 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/79 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2705542

Methods and compositions are disclosed to engineer plastids comprising heterologous genes encoding immuno-activating domains fused to an extracellular domain (ECD) of a receptor or surface glycoprotein, a growth factor or an enzyme and produced within a subcellular organelle, such as a chloroplast. The immuno- activating domains may include those regions of a protein capable of modulating the interaction between immune effector cells via proteins containing stereoselective binding domains and specific ligands, such as the Fc regions of antibodies. The present disclosure also demonstrates the utility of plants, including green algae, for the production of complex multi-domain fusion proteins as soluble bioactive therapeutic agents.

L'invention concerne des procédés et des compositions pour la mise au point génétique de plastes comprenant des gènes hétérologues qui codent pour des domaines d'immuno-activation, fusionnés à un domaine extracellulaire (ECD) d'un récepteur ou d'une glycoprotéine de surface, à un facteur de croissance ou à une enzyme et produits à l'intérieur d'un organite sous-cellulaire tel qu'un chloroplaste. Les domaines d'immuno-activation comprennent les régions d'une protéine capables de moduler l'interaction entre des cellules effectrices immunitaires par l'intermédiaire de protéines contenant des domaines de liaison stéréosélectifs et des ligands spécifiques, tels que les régions Fc d'anticorps. L'invention démontre aussi l'utilité de végétaux, y compris les algues vertes, pour la production de protéines hybrides complexes multidomaines comme agents thérapeutiques bioactifs solubles.

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