Production of fibrinogen in transgenic animals

Details Production of fibrinogen in transgenic animals Production of fibrinogen in transgenic animals

A - Human Necessities

01

K

A01K 67/027 (2006.01) A61D 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2309891

Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A.alpha., B.beta. and .gamma. chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.

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