C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/06 (2006.01) C12N 1/18 (2006.01)
Patent
CA 2562772
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal .beta.-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.
L'invention concerne une nouvelle cellule hôte eucaryote inférieure produisant des glycoprotéines humaines caractérisées en ce qu'elle possèdent un résidu .beta.-galactose terminal et qu'elles sont sensiblement exemptes de résidus fucose et acide sialique. L'invention porte également sur un procédé de catalyse du transfert d'un résidu UDP-galactose vers un substrat receveur dans une cellule hôte eucaryote inférieure de recombinaison, pouvant être utilisée en tant que glycoprotéine thérapeutique.
Bobrowicz Piotr
Choi Byung-Kwon
Davidson Robert
Gerngross Tillman
Hamilton Stephen
Glycofi Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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