Production of glycoproteins with modified fucosylation

C - Chemistry – Metallurgy – 12 – N

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C12N 1/19 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2679732

Methods are disclosed for genetically engineering host cells that lack an endogenous pathway for fucosylating N-glycans of glycoproteins to be able to produce glycoproteins with fucosylated N-glycans.

L'invention porte sur des méthodes d'obtention par génie génétique de cellules hôtes dépourvues de mécanisme endogène pour la fucosylation de N-glycanes de glycoprotéines, leur permettant de produire des glycoprotéines à N-glycanes fucosylés.

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