Production of high mannose proteins in plant culture

Details Production of high mannose proteins in plant culture Production of high mannose proteins in plant culture

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 38/47 (2006.01) A61P 43/00 (2006.01) C12N 1/21 (2006.01) C12N 9/24 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2523539

A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.

L'invention concerne un dispositif, un système et un procédé pour la production de protéines glycosylées dans la culture végétale, notamment des protéines de glycosylation riches en mannose, alors que lesdites protéines sont ciblées à l'aide d'un signal ER et/ou en contournant l'appareil de Golgi. L'invention porte également sur des vecteurs et sur des procédés pour l'expression et la production d'enzymes lysosomales riches en mannose et à activité enzymatique élevée, au moyen de racine de plante transgénique, notamment de cellules de carottes. L'invention porte plus particulièrement sur des cellules hôtes, notamment sur des cellules de carotte suspendues transgéniques, sur des vecteurs et sur des procédés pour l'expression et la production à haut rendement de glucocérébrosidase (GCD) riche en en mannose et biologiquement active. Elle concerne encore des compositions et des procédés de traitement de maladies lysosomales.

Affiliated with

Also associated with

Rating

Production of high mannose proteins in plant culture does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Production of high mannose proteins in plant culture, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of high mannose proteins in plant culture will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1962870