Production of highly isotopically labelled, secondary,...

C - Chemistry – Metallurgy – 12 – P

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C12P 1/02 (2006.01) C12P 1/04 (2006.01)

Patent

CA 2602415

The invention relates to a method for producing isotopically labelled secondary metabolic products of fungi or bacteria in a liquid synthetic culture medium. According to said method, the synthesis is carried out by immobilising the fungi or bacteria on an inert carrier, adding a liquid synthetic culture medium in which essentially all of the carbon atoms, nitrogen atoms and/or sulphur atoms are replaced by stable isotopes.

L'invention concerne un procédé permettant de produire des métabolites secondaires hautement isotopiques de champignons ou de bactéries dans un milieu de culture synthétique liquide. Selon ce procédé, la synthèse s'effectue par immobilisation des champignons ou des bactéries sur un support inerte, sous apport de milieu de culture synthétique liquide, dans lequel sensiblement tous les atomes de carbone, d'azote et/ou de soufre ont été remplacés par des isotopes stables.

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