Production of l-lysine by genetically modified...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/77 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 15/52 (2006.01) C12P 1/04 (2006.01) C12P 13/04 (2006.01) C12P 13/08 (2006.01) C12P 19/30 (2006.01) C12P 19/38 (2006.01)

Patent

CA 2455878

The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.

L'invention porte sur des bactéries coryneformes qui, en plus d'une copie au moins, présente au site naturel (locus) d'un cadre de lecture ouvert (ORF), d'un gène ou d'un allèle, codant pour la synthèse d'une protéine ou d'un ARN, produisent, dans chaque cas une deuxième copie et éventuellement une troisième ou une quatrième copie présentes dans chaque cas dans un deuxième site ou éventuellement dans un troisième ou une quatrième site, sous une forme intégrée au chromosome. L'invention porte également sur un procédé de préparation de composés chimiques par fermentation de ces bactéries.

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