C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/078 (2010.01) C12N 5/0789 (2010.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2328425
The present invention is directed to hematopoietic progenitor cells isolated from a tissue specimen, such as marrow cells or peripheral blood, and to the method of co-culturing isolated hematopoietic progenitor cells with human mesenchymal stem cells to induce megakaryocyte differentiation and platelet production. In addition, hematopoietic stem cells can be genetically engineered to carry genes of interest particularly for the expression of physiologically active proteins. In the presence of mesenchymal stem cells, the transduced cells carry the new genetic material and express gene products that can be used to modulate blood disorders.
L'invention concerne des cellules hématopoïétiques parentes isolées dans un spécimen tissulaire, tel que des cellules médullaires ou du sang périphérique, et le procédé de co-culture de cellules hématopoïétiques parentes isolées à l'aide de cellules souches mésenchymateuses humaines, de sorte qu'une différentiation mégacaryocytaire et une production de plaquettes soient induites. Par ailleurs, les cellules souches hématopoïétiques peuvent être manipulées génétiquement de manière qu'elles portent des gènes particulier, notamment pour l'expression de protéines actives au plan physiologique. En présence de cellules souches mésenchymateuses, les cellules transduites portent le nouveau matériel génétique et expriment des produits géniques pouvant être utilisés pour la modulation de troubles sanguins.
Qasba Pankaj
Thiede Mark A.
Osiris Therapeutics Inc.
Smart & Biggar
LandOfFree
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